Sebaceous Granulomas: A Novel Feature of Discoid Lupus Erythematosus
نویسندگان
چکیده
Rifat Yasmin, Ikramullah Khan, Anwar Ul Haque, Syed Afaq Ahmad Objective: To determine the frequency of sebaceous granulomas formation in discoid lupus erythematosus. Study Design: Retrospective observational study. Setting: Departments of Dermatology and Pathology, Pakistan Institute of Medical Sciences, Islamabad. Material and Methods: 100 cases of Discoid Lupus Erythematosus (DLE)spanning over two years and with the age range of 3 years to 70 years were examined for the presence of Sebaceous Granuloma. Other features of DLE like hyperkeratosis, follicular plugging, epidermal atrophy, basal layer vacuolization, basement membrane deposits, pigmentary incontinence, perivascular inflammation, periappendigeal inflammation, and collagen damage were also noted. Introduction: Lupus erythematosus is an immune complex, type III hypersensitivity disease where antibodies are formed against native Deoxyribose Nucleic Acid (DNA). The immune compexes are deposited in various organs and various sites causing marked pleotropism. If several systems are involved then the disease is named Systemic Lupus Erythematosus (SLE) and if skin is exclusively involve the term Discoid Lupus Erythematosus (DLE) is used. One of the several features of DLE includes periappengeal inflammation. This may at times completely wipe out sebaceous glands forming sebaceous granulomas. Results: Out of these 100 cases 8 cases contained sebaceous granulomas. These granulomas were composed of epithelioid cells, foreign body giant cells containing partially digested sebaceous material and a few lymphoctytes. Conclusion: Sebaceous granulomas formation was seen in 8 % cases of discoid lupus erythematosus. This feature must be recognized both by dermatologists and pathologist so that diagnosis of DLE may not be distracted and erroneous diagnosis due to presence of granulomas may not be rendered.
منابع مشابه
A Case Report of Phakomatosis Pigmentovascularis in a Patient with Discoid Lupus Erythematosus and Epidermal Naevus
We report phakomatosis pigmentovascularis (PPV) detected in a 40- year-old male characterized by the presence of a port-wine stain in the background of aberrant Mongolian spots covering the back, nevus of Ota, ocular melanosis, epidermal nevus and a scaly patch with the diagnosis of discoid lupus erytematosus. These associations have not been reported yet.
متن کاملImmunohistochemistry profile of inflammatory cells in lichen planopilaris and discoid lupus erythematosus
Background: Scarring (cicatricial) alopecia represents a complex group of inflammatory disorders, mainly characterized by destruction of the hair follicle unit. Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the two main causes of primary cicatricial alopecia (PCA), both leading to hair follicle destruction and irreversible alopecia. However, they are different in pathogene...
متن کاملDescriptive study of patients with discoid Lupus Erythematosus referred to Razi Hospital in Tehran in 1377
Background: Discoid lupus erythematosus (DLE) is a variety of lupus disease characterized with sticky thick scaces telangiectasia and follicular plugging. Objectives: To determine the relative frequency of clinical, paraclinical and pathological findings in patients with DLE. Patients and Methods: The clinical, Paraclinical and pathological findings in 50 biopsy proven patients with DLE referre...
متن کاملScalp sarcoidosis mimicking discoid lupus erythematosus with lichenoid features in histology
متن کامل
Laboratory findings in discoid Lupus Erythematosus: A study on 51 patients in skin clinic of Shahid Faghihi Hospital, Shiraz, 1998-2000
Background: Discoid Lupus Erythematosus (DLE) is chronic, recurrent and relatively benign skin disorder. Objective: The purpose of this study was to investigate the laboratory tests (ANA, LE-Cell, ESR, CRP, RF, VDRL, WBC, PLT) in patients with DLE. Patients and Methods: In this study, laboratory tests of 51 patients with DLE who referred to the Dermatology clinic of Shahid Faghihi Hospital in S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010